I am Nobuyoshi Kosaka who is a visiting researcher supported by the Japan Society for the Promotion of Science (JSPS). I have worked in the variety of research fields, such as neurology, haematology, microRNA bilogy, exosome biology and usually in relation cancer. I have been investigating cancer development and been involved in developing both novel therapeutic and diagnostic approaches against cancer. My current research interest is in the cooperation and competition among the cells and the roles of these processes in disease progression resulting from a mis-regulated genetic status.
I believe a number of mysteries regarding cancer in multicellular organisms can be revelaed by studying relevant cell biology in planaria. Especially, 1) How do normal stem cells transform into cancer causing cells? 2) What are the boundaries between regeneration/tissue homeostasis and cancer and how are they crossed? 3) What is the role of protection mechanisms in cancer in the evolution of metazoan life history traits such as lifespan and use of adult stem cells. I hope this knowledge am deeper understandings will not only underpin the development of strategies for cancer prevention, detection and treatment but also lead us to understand our own evolutionary history more deeply.
Kosaka N, Yoshioka Y, Tominaga N, Hagiwara K, Katsuda T, Ochiya T. Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy. Future Oncol. 2014 Mar;10(4):671-81.
Yoshioka Y, Kosaka N, Konishi Y, Ohta H, Okamoto H, Sonoda H, Nonaka R, Yamamoto H, Ishii H, Mori M, Furuta K, Nakajima T, Hayashi H, Sugisaki H, Higashimoto H, Kato T, Takeshita F, Ochiya T. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nat Commun. 2014 Apr 7;5:3591. doi: 10.1038/ncomms4591.
Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Katsuda T, Ochiya T. Trash or Treasure: extracellular microRNAs and cell-to-cell communication. Front Genet. 2013 Sep 5;4:173.
Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Ochiya T. Functional analysis of exosomal microRNA in cell-cell communication research. Methods Mol Biol. 2013;1024:1-10.
Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem. 2013 Apr 12;288(15):10849-59.
nobuyoshi.kosaka at zoo.ox.ac.uk
2008 Ph.D (Molecular physiology)
Major in Integrative Bioscience and Biomedical Engineering, Graduate School of Science and Engineering,Waseda University, Tokyo, Japan
2005 M.Sc. (Molecular physiology)
Major in Integrative Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University, Tokyo, Japan
2003 B.Sc. (Molecular physiology)
Department of Biology, School of Education, Waseda University, Tokyo, Japan
2011 – 2013 National Cancer Center Research Institute, Tokyo, Japan
Staff Scientist –Molecular and Cellular Medicine
2009 – 2011 National Cancer Center Research Institute, Tokyo, Japan
Research Resident –Section for Studies on Metastasis
2008 – 2009 National Cancer Center Research Institute, Tokyo, Japan
Postdoctoral Fellow – National Cancer Center Research Institute
2008 – 2009 Japan Society for the Promotion of Science, Tokyo, Japan
Research Fellow (Postdoctoral) – National Cancer Center Research Institute
2007 – 2008 Japan Society for the Promotion of Science, Tokyo, Japan
Research Fellow (Doctoral) – Waseda University