Research

I am Nobuyoshi Kosaka who is a visiting researcher supported by the Japan Society for the Promotion of Science (JSPS). I have worked in the variety of research fields, such as neurology, haematology, microRNA bilogy, exosome biology and usually in relation cancer. I have been investigating cancer development and been involved in developing both novel therapeutic and diagnostic approaches against cancer. My current research interest is in the cooperation and competition among the cells and the roles of these processes in disease progression resulting from a mis-regulated genetic status.

I believe a number of mysteries regarding cancer in multicellular organisms can be revelaed by studying relevant cell biology in planaria. Especially, 1) How do normal stem cells transform into cancer causing cells? 2) What are the boundaries between regeneration/tissue homeostasis and cancer and how are they crossed? 3) What is the role of protection mechanisms in cancer in the evolution of metazoan life history traits such as lifespan and use of adult stem cells. I hope this knowledge am deeper understandings will not only underpin the development of strategies for cancer prevention, detection and treatment but also lead us to understand our own evolutionary history more deeply.

 

Selected publications

Kosaka N, Yoshioka Y, Tominaga N, Hagiwara K, Katsuda T, Ochiya T. Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy. Future Oncol. 2014 Mar;10(4):671-81.

Yoshioka Y, Kosaka N, Konishi Y, Ohta H, Okamoto H, Sonoda H, Nonaka R, Yamamoto H, Ishii H, Mori M, Furuta K, Nakajima T, Hayashi H, Sugisaki H, Higashimoto H, Kato T, Takeshita F, Ochiya T. Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen. Nat Commun. 2014 Apr 7;5:3591. doi: 10.1038/ncomms4591.

Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Katsuda T, Ochiya T. Trash or Treasure: extracellular microRNAs and cell-to-cell communication. Front Genet. 2013 Sep 5;4:173.

Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Ochiya T. Functional analysis of exosomal microRNA in cell-cell communication research. Methods Mol Biol. 2013;1024:1-10.

Kosaka N, Iguchi H, Hagiwara K, Yoshioka Y, Takeshita F, Ochiya T. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J Biol Chem. 2013 Apr 12;288(15):10849-59.

Email

nobuyoshi.kosaka at zoo.ox.ac.uk

 

Education

2008 Ph.D  (Molecular physiology)

Major in Integrative Bioscience and Biomedical Engineering, Graduate School of Science and Engineering,Waseda University, Tokyo, Japan

2005 M.Sc.  (Molecular physiology)

Major in Integrative Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University, Tokyo, Japan

2003 B.Sc. (Molecular physiology)

Department of Biology, School of Education, Waseda University, Tokyo, Japan

 

Professional Experience

2011 – 2013  National Cancer Center Research Institute, Tokyo, Japan

Staff Scientist –Molecular and Cellular Medicine

2009 – 2011  National Cancer Center Research Institute,  Tokyo, Japan

Research Resident –Section for Studies on Metastasis

2008 – 2009  National Cancer Center Research Institute, Tokyo, Japan

Postdoctoral Fellow – National Cancer Center Research Institute

2008 – 2009  Japan Society for the Promotion of Science,  Tokyo, Japan

Research Fellow (Postdoctoral) – National Cancer Center Research Institute

2007 – 2008  Japan Society for the Promotion of Science,  Tokyo, Japan

Research Fellow (Doctoral) – Waseda University

 

Nationality

Japan