Research

I am currently a postdoctoral scientist at the Aboobaker lab.

I started my scientific career doing a BSc in Psychology in University of Nottingham. During my degree, I cultivated an interest in Genetics and Molecular Biology and, as a result, did my Masters by Research in Molecular Genetics in the Aboobaker lab. During that time I was working on the establishment of a model combining three different tools (RNAi, irradiation and bioinformatics) to aid the identification of stem cell-specific genes. After my Masters course, I stayed for a PhD. My PhD work focused on studying the function of the frequently mutated in cancer MLL3 and MLL4 histone methyltransferases. The work suggests that the flatworm system could be used convincingly for in-depth studies of cancer epigenetics.

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Publications

Publications:

Mihaylova, Y., Kao, D., Hughes, S., Lai, A., Jaber-Hijazi, F., Abnave, P., Kosaka, N. and Aboobaker, A. A. (manuscript in prep) MLL3/4 prevents stem cell hyperplasia and controls differentiation programs in a planarian cancer stem cells model.

Tejada-Romero, B., Carter, J.-M., Mihaylova, Y., Neumann, B., and Aboobaker, A.A. (2015). JNK signalling is necessary for a Wnt and stem cell-dependent regeneration programme. Development 142, 2413–2424.

Mihaylova, Y., and Aboobaker, A.A. (2013). What is it about “eye of newt”? Genome Biology 14, 106.

Jaber-Hijazi, F., Lo, P.J.K.P., Mihaylova, Y., Foster, J.M., Benner, J.S., Tejada Romero, B., Chen, C., Malla, S., Solana, J., Ruzov, A., et al. (2013). Planarian MBD2/3 is required for adult stem cell pluripotency independently of DNA methylation. Developmental Biology 384, 141–153.

Solana, J., Gamberi, C., Mihaylova, Y., Grosswendt, S., Chen, C., Lasko, P., Rajewsky, N., and Aboobaker, A.A. (2013). The CCR4-NOT Complex Mediates Deadenylation and Degradation of Stem Cell mRNAs and Promotes Planarian Stem Cell Differentiation. PLoS Genetics 9, e1004003.

Solana, J., Kao, D., Mihaylova, Y., Jaber-Hijazi, F., Malla, S., Wilson, R., and Aboobaker, A. (2012). Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNA-seq, RNA interference and irradiation approach. Genome Biology 13, R19.

Email

yuliana.mihaylova@gmail.com

Education

BSc Psychology (award for highest degree result), University of Nottingham

MRes Molecular Genetics, University of Nottingham

PhD Genetics, University of Nottingham 2016